Tsitsipas vs Muller Prediction and Betting Tips

US Open 2025: Tsitsipas vs Muller Preview, Prediction and Betting Tips

The US Open has kicked off with style, delivering plenty of round-of-128 thrillers right from the start. As players fight their way for a spot in the second round, Tuesday, August 26, sets the stage for another intense showdown between Stefanos Tsitsipas and Alexandre Muller. This matchup opens up plenty of betting opportunities, and we’ve done the number-crunching for you. Sit back and dive into our Tsitsipas vs Muller prediction and betting tips.

Player Form: Tsitsipas Fumbling

Tsitsipas’s season so far hasn’t exactly been smooth sailing. The Greek has faced several early-round exits across different tournaments and is still struggling to find his groove. However, he’s still put together a 20-16 win-loss record and bagged an ATP 500 title in Dubai. The former world No. 3 has been doing his best to log in valuable court time, hoping it helps him step into New York with a boost of confidence.

Muller hasn’t had an impressive season either, with a fairly average season so far. Just last week, he suffered a third-round exit at Winston-Salem against Giovanni Mpetshi Perricard, following a first-round exit in Cincinnati. His win-loss record stands at 20-20, with no standout performances to highlight, though he does have an ATP 250 title in Hong Kong to his name.

From the Bookies’ Perspective: A Tight Matchup

The odds for this encounter aren’t leaning too heavily in either direction, but Tsitsipas’ ranking, past performances, and career achievements tip the scales slightly in his favour, making him the favourite for Bookmaker Betway at 11/20. Meanwhile, Muller is slightly behind at 7/5. Set betting suggests a 3-1 victory for Tsitsipas, with this outcome paying 13/4.

Head-to-Head Stats

Tsitsipas and Muller have faced each other twice before this encounter. Their first matchup came in the third round of the ATP 1000 in Shanghai, where Tsitsipas claimed a 6-3, 7-5 win. While their recent encounter was in the ATP 1000, Rome, with Tsitsipas once again coming out on top, 6-2, 7-6(3). Hence, their head-to-head stands at 2-0 in favour of the Greek.

Key Factors to Keep In Mind

Tsitsipas is clearly the stronger player in terms of statistics, but his vulnerable backhand is an area Muller could look to exploit. Adding to that, his drop in focus and commitment has been an issue, chipping away at his confidence. Earlier this year, he bowed out in the first round of the Australian Open and hasn’t managed any standout performances since. A lingering back injury, troubling him since 2024, has only added to his struggles.

That said, New York offers Tsitsipas a real chance at redemption. He’ll be eager to shift the momentum, rediscover his rhythm, and push deeper into the tournament.

Tsitsipas vs Muller Prediction and Betting Tips

This clash looks set to stretch into four sets, with both players likely to give their all on the court. The edge seems to tilt slightly in Tsitsipas’s favour to be the victor of this encounter. Here are a few betting options worth considering for this matchup:

  • Tsitsipas to Win 3-1 @ 13/4
  • Total Games Over 36.5 @ 3/5
  • Set One Winner Tsitsipas @ 3/5
  • Both Players to Win a Set @ 4/7

Tsitsipas and Muller are going to stand off against each other at 2:00 P.M. CEST, on Court 7 of the Billie Jean King National Tennis Centre, New York.

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